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<head>
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<title>A PRACTICAL GUIDE TO FEMINIZING HRT</title>
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<h3 class="ltx_title ltx_title_subsection">
<span class="ltx_tag ltx_tag_subsection">3.11 </span>How do I dose <span class="ltx_text ltx_font_italic">estradiol valerate</span>?</h3>
<div class="ltx_para" id="S3.SS11.p1">
<p class="ltx_p">Either twice a week at a lower dosage or once a week at a higher dosage is necessary for good levels with <span class="ltx_text ltx_font_italic">estradiol valerate</span>. It is a matter of comfort and tolerance. The typical rule of thumb is about 1mg for every day in a cycle with frequencies generally between 3-7 days. A weekly dosage between 6-8mg is my typical recommendation, but 4-5mg per 5 days is also very common. <span class="ltx_text ltx_font_bold">The frequency should never be less often than weekly (i.e., No more than seven days between injections).</span> Weekly is already pushing how long the ester can last. Anything further is highly discouraged to avoid side effects related to variance (See Question <a class="ltx_ref" href="#S7.SS3" title="7.3 I feel really bad on my trough days. What should I do? ‣ 7 TROUBLESHOOTING ‣ A PRACTICAL GUIDE TO FEMINIZING HRT"><span class="ltx_text ltx_ref_tag">7.3</span></a>).</p>
<p class="ltx_p">Either twice a week at a lower dosage or once a week at a higher dosage is necessary for good levels with <span class="ltx_text ltx_font_italic">estradiol valerate</span>. It is a matter of comfort and tolerance. The typical rule of thumb is about 1mg for every day in a cycle with frequencies generally between 3-7 days. <span class="ltx_text ltx_font_bold">A weekly dosage between 6-8mg is my typical recommendation</span>, but 4-5mg per 5 days is also very common. <span class="ltx_text ltx_font_bold">The frequency should never be less often than weekly (i.e., No more than seven days between injections).</span> Weekly is already pushing how long the ester can last. Anything further is highly discouraged to avoid side effects related to variance (See Question <a class="ltx_ref" href="#S7.SS3" title="7.3 I feel really bad on my trough days. What should I do? ‣ 7 TROUBLESHOOTING ‣ A PRACTICAL GUIDE TO FEMINIZING HRT"><span class="ltx_text ltx_ref_tag">7.3</span></a>).</p>
</div>
<div class="ltx_para" id="S3.SS11.p2">
<p class="ltx_p">Please note that in some regions pills are confusingly sold with the name <span class="ltx_text ltx_font_italic">estradiol valerate</span>, but this section only refers to the injectable form.</p>
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<div class="ltx_para ltx_noindent" id="Sx6.p23">
<p class="ltx_p">2025-10-10: Added Question <a class="ltx_ref" href="#S11.SS42" title="11.42 How does HRT affect fertility? ‣ 11 MYTHS AND MISCS ‣ A PRACTICAL GUIDE TO FEMINIZING HRT"><span class="ltx_text ltx_ref_tag">11.42</span></a> and Question <a class="ltx_ref" href="#S11.SS43" title="11.43 Is infertility from HRT reversible? ‣ 11 MYTHS AND MISCS ‣ A PRACTICAL GUIDE TO FEMINIZING HRT"><span class="ltx_text ltx_ref_tag">11.43</span></a> per request. Honestly I just forgot about fertility being a thing lol. Also added the Friends Of PGHRT postword section. 19.5k words.</p>
</div>
<div class="ltx_para ltx_noindent" id="Sx6.p24">
<p class="ltx_p">2025-10-10: Added Gretchen’s Version (.txt) and fixed formatting. 19.5k words.</p>
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