Either twice a week at a lower dosage or once a week at a higher dosage is necessary for good levels with estradiol valerate. It is a matter of comfort and tolerance. The typical rule of thumb is about 1mg for every day in a cycle with frequencies generally between 3-7 days. A weekly dosage between 6-8mg is my typical recommendation, but 4-5mg per 5 days is also very common. The frequency should never be less often than weekly (i.e., No more than seven days between injections). Weekly is already pushing how long the ester can last. Anything further is highly discouraged to avoid side effects related to variance (See Question 7.3).
+Either twice a week at a lower dosage or once a week at a higher dosage is necessary for good levels with estradiol valerate. It is a matter of comfort and tolerance. The typical rule of thumb is about 1mg for every day in a cycle with frequencies generally between 3-7 days. A weekly dosage between 6-8mg is my typical recommendation, but 4-5mg per 5 days is also very common. The frequency should never be less often than weekly (i.e., No more than seven days between injections). Weekly is already pushing how long the ester can last. Anything further is highly discouraged to avoid side effects related to variance (See Question 7.3).
Please note that in some regions pills are confusingly sold with the name estradiol valerate, but this section only refers to the injectable form.
@@ -2766,11 +2766,14 @@2025-10-10: Added Question 11.42 and Question 11.43 per request. Honestly I just forgot about fertility being a thing lol. Also added the Friends Of PGHRT postword section. 19.5k words.
2025-10-10: Added Gretchen’s Version (.txt) and fixed formatting. 19.5k words.
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