============================================================================ NOTE: If you're on mobile and the formatting is messed up, try rotating your phone to ensure the optimum ASCII art experience. ============================================================================ XXXXXXXXXXXXX XXXXX / |___ \ XXXXX XXX _ _ | | __) | _ XXX XX / / | | |/ __/ / | XX X | | | |_|_____| | | X XX | | | | | ____ XX X_ ___ |_|_| |_| |___ \ X X/ |/ _ \ __) | X X | | | | | / __/ X X | | |_| | |_____| X X |_|\___/ _____ X X / _ \ |___ / X X| (_) | |_ \ X X \__, | ___) |X X /_/ |____/ X X ___ _ _ X X ( _ ) | || | X X / _ \ | || |_ X X| (_) | _____ ____ |__ _|X X\___/ |___ | __ | ___| |_|XX X / / / /_ |___ \ X XX / / | '_ \ ___) | XX XXX/_/ | (_) | |____/XXX XXXXX \___/ XXXXX XXXXXXXXXXXXX ___ / | / /| | / ___ | /_/ _|_| __ _ __ ______ _ __ / __ \_________ ______/ /_(_)________ _/ / / ____/_ __(_)___/ /__ / /_/ / ___/ __ `/ ___/ __/ / ___/ __ `/ / / / __/ / / / / __ / _ \ / ____/ / / /_/ / /__/ /_/ / /__/ /_/ / / / /_/ / /_/ / / /_/ / __/ /_/___/_/ \__,_/\___/\__/_/\___/\__,_/_/ \____/\__,_/_/\__,_/\___/ /_ __/___ / / / __ \ / / / /_/ / /_/ _\____/ _ _ _ __ ______ ______ / ____/__ ____ ___ (_)___ (_)___ (_)___ ____ _ / / / / __ \/_ __/ / /_ / _ \/ __ `__ \/ / __ \/ /_ / / / __ \/ __ `/ / /_/ / /_/ / / / / __/ / __/ / / / / / / / / / / / /_/ / / / / /_/ / / __ / _, _/ / / /_/ \___/_/ /_/ /_/_/_/ /_/_/ /___/_/_/ /_/\__, / /_/ /_/_/ |_| /_/ /____/ ============================================================================ ====================A Practical Guide To Feminizing HRT===================== ============================================================================ ============A comprehensive FAQ/Walkthrough for Feminizing HRT============== ============================================================================ =="The Time Cube of HRT guides" - gretchen (@humanremains.northsky.social)== ============================================================================ ===================By: Katie Tightpussy (@katie.bzky.team)================== ===========================October 27, 2025================================= =============================Version 1.28=================================== ============================================================================ ============================================================================ ATTENTION! For easy navigation, press CTRL + F and type in your search string. This FAQ, and all of my posts/guides/clock drawings, are now dedicated to the over 3,000 innocent people killed in the World Trade Center and Pentagon terrorist attacks in New York City, New York, and Washington, D.C., on September 11, 2001. To all of the innocent working people, and FDNY Firemen, as well as other emergency workers, you will always be remembered. We won't stop until we bring these criminals to justice, your deaths were NOT IN VAIN! God Bless America, death to all terrorists of all races everywhere. ============================================================================ A Practical Guide To Feminizing HRT Katie Tightpussy Helpfully modified into a 90s-00s style .txt file by gretchen (@humanremains.northsky.social) for Gen X and Millennial readers, mostly because I thought it'd be funny. (October 27, 2025) ============================================================================ DISCLAIMER ============================================================================ I am not a doctor. I do not work in medicine. I am not a medical professional in any capacity. I am a layperson offering lay opinions based on the extent of my own education and experiences. All information and assertions below should be treated accordingly as mere opinion rather than statement of fact or medical advice. This guide prioritizes community moral truth where scientific research falters. Basically, don’t get mad at me. ============================================================================ T A B L E O F C O N T E N T S... ============================================================================ | Chapter | Title | CTRL+F Code | |--------------------------------------------------------------------------- | 0 | FOREWARD | Alpha | |--------------------------------------------------------------------------- | 0.1 | DEDICATION | Beta | |--------------------------------------------------------------------------- | 1 | INTRODUCTION | Gamma | |--------------------------------------------------------------------------- | 2 | WHY INJECTIONS | Delta | |--------------------------------------------------------------------------- | 3 | TYPES AND DOSAGES | Epsilon | |--------------------------------------------------------------------------- | 4 | BLOOD TESTS AND LEVELS | Zeta | |--------------------------------------------------------------------------- | 5 | TECHNIQUE AND SUPPLIES | Eta | |--------------------------------------------------------------------------- | 6 | SOURCING VIALS | Theta | |--------------------------------------------------------------------------- | 7 | TROUBLESHOOTING | Iota | |--------------------------------------------------------------------------- | 8 | PROGESTERONE | Kappa | |--------------------------------------------------------------------------- | 9 | TESTOSTERONE | Lambda | |--------------------------------------------------------------------------- | 10 | ANTIANDROGENS | Mu | |--------------------------------------------------------------------------- | 11 | MYTHS AND MISCS | Nu | |--------------------------------------------------------------------------- | 12 | CREATINE | Xi | |--------------------------------------------------------------------------- | 13 | CLOSING REMARKS | Omicron | |--------------------------------------------------------------------------- | 13.1 | FRIENDS OF PGHRT | Pi | |--------------------------------------------------------------------------- | 13.2 | ABOUT THE AUTHOR | Rho | |--------------------------------------------------------------------------- | 13.3 | DISCLOSURES | Sigma | |--------------------------------------------------------------------------- | 13.4 | ACKNOWLEDGEMENTS | Tau | |--------------------------------------------------------------------------- | 13.5 | CHEAT CODES | Upsilon | |--------------------------------------------------------------------------- | 13.6 | CHANGELOG | Phi | ============================================================================ ============================================================================ 0 - FOREWORD ============================================================================ --------------------- | CTRL+F Code = Alpha | --------------------- The purpose of this living document is to catalogue my thoughts and opinions regarding feminizing HRT because I believe that the various community wikis are impractical. They are valuable resources, but in my view these wikis lack utility for people who are more interested in clear actionable guidance than they are in learning every semi-relevant biological progress and graph. I aim to provide an exhaustive quick reference guide of simplified direct answers to the most common questions on how to safely and effectively perform HRT that I have received over the years with the goal of demystifying this life saving medicine both for people considering HRT and for established transsexuals. As such, I assume a baseline familiarity with the effects of HRT. In case you are not familiar: HRT does a lot and probably more than you think. It’s great. Changing your sex is really cool and fun. I recommend it. You deserve quality transition healthcare and are capable of making the best decisions for yourself. I hope that this document can be a useful tool in your decision-making process and a starting point for further learning if that is your interest. And stay off the trans subreddits, too. Just trust me on that one, okay? Or at the very least /r/mtf since that one is particularly bad. Neither healthy places nor sources of good wisdom. You’ll be pulling rotten brain worms out for years. Best advice I can give. As for the fellas, sections of this are still highly relevant, but obviously there are key differences in goals and outcomes. This guide for masculinizing HRT [Warning: Google Docs link (https://docs.google.com/document/d/ 1DXFxzN0XTudPZez_SO61fpqncRLPH_Be_QG_8Pcz9LU/edit?tab=t.0)] looks pretty solid, but I haven’t examined it in full depth, so use your brain and your judgement. Anyway they should make a tboy Katie Tightpussy. Oliver Longdick or something. Maybe Xavier. If you would like to donate to support this project, CashApp(https://cash.app/Katitties), Ko-Fi(https://ko-fi.com/katitties), and Venmo(https://account.venmo.com/u/katitties) all work. I appreciate it! How to Use This Document This document is structured linearly as a series of questions and answers such that broadly-speaking each question and section flows into the next. I encourage reading it top-to-bottom as that should hopefully answer any questions (including ones you didn’t know that you had) in a conversational narrative, but obviously this is lengthy. Take your time and read it in pieces if you wish. You can use the table of contents to navigate to a particular section or question as needed, especially when re-visiting. I recommend saving this page/document so that you can refer back to it any time you have questions about your HRT. It is a lot to absorb up front, so it’s okay if it doesn’t! No rush on any of this. This document can also be downloaded as a PDF (https://pghrt.diy/pghrt.pdf). Please do so. Alternatively, you can read a modern html version if you are inclined (https://pghrt.diy/). It will be updated more frequently than this .txt version. If you are interested in doing a translation or any other alternate version, please get in touch! ============================================================================ DEDICATION ============================================================================ --------------------- | CTRL+F Code = Beta | --------------------- This document is dedicated to all of our sisters who did not make it. May we carry the light of their torch into another day. ============================================================================ 1 - INTRODUCTION ============================================================================ --------------------- | CTRL+F Code = Gamma | --------------------- 1.1 Is taking estrogen safe? With modern bioidentical hormones, HRT could not be much safer. You’re just flipping the primary juice that your body runs on and shifting the balance of hormones that are already in your body. Even where the details of optimization get complex, the core principle of changing your biology is highly forgiving. The body is malleable and you will be able to adjust to what feels right for you. 1.2 What route of administration should I choose for estrogen? Injections. They are on the whole the most effective, easy, consistent, safe, and inexpensive form of HRT. For some, injections become a ritual to look forward to, and others they can become quite fun. But remember: any estrogen is better than no estrogen. 1.3 Why do you not recommend pills, patches, or gel? Chiefly, all three have major downsides that injections do not. It is not that they do not work, it is that you deserve better than being forced to tolerate major downsides. Let me reiterate: all forms of HRT can produce satisfactory results, but that does not mean all forms of HRT are equal or good. 1.4 Is dosage of estrogen equivalent across administration routes or forms? No. This is important enough that I did not relegate it to Section 11 “MYTHS AND MISCS”. Estrogen dosages cannot be directly compared across type or form. 1mg of one is not 1mg of another. Different types and forms have different properties that affect how much estrogen is absorbed into the body (“bioavailability”), at what rate, and the resulting half-life. 1.5 What is a “half-life”? In simple terms, the half-life of a substance is the time it takes until half of that substance is eliminated. In the context of HRT, this is what determines how long a dosage stays active in your system, and thus your dosing frequency. This is referred to as your hormone cycle, and it forms a curve. Levels go up, they peak, and then they fall. The properties of this curve (how estrogen levels change over time) are important. 1.6 What’s wrong with pills? The largest issue with pills is that they carry increased long term blood clotting and liver coagulation risks. The severity of these risks can be mitigated in part by taking them sublingually or buccally (dissolving the pill either underneath your tongue or between your gum and cheek, respectively) as opposed to orally (swallowing the pill normally) to avoid first-pass metabolism in the liver. Even with sublingual and buccal methods, however, it’s common to ingest some amount of the pill, so it’s fair to assume that at least some risk remains. Please understand that the absolute risk is still low (e.g., acetaminophen has an order of magnitude more liver concerns than estrogen), however this risk compounds even further with nicotine-related estrogen risk. See Question 11.2 as well. Beyond this, numerous other issues with pills stem from two main characteristics: 1) their short half-life and poor bioavailability, and 2) their common necessitation of antiandrogens. The former characteristic makes pills largely unsuitable for monotherapy (discussed below) when compared to injections. The latter often comes with an assortment of negative side effects depending on the antiandrogens involved (see Section 10 “ANTIANDROGENS”). Together, these characteristics add additional degrees of variability that make poor regimens and their side effects (such as poor energy/libido and slower results) more common than with other administration routes. Pills are also more difficult to stockpile, and in some marketplaces are more expensive than vials. Please also note that importing pills from foreign distributors in large volumes may run afoul of customs which may lead to seizure, financial loss, and/or possible legal trouble depending on your country’s laws. If anyone asks, you don’t know who ordered those pills. If you are on pills for whatever reason, please take 4-8mg sublingually spaced throughout the day. Under 4mg is almost never a sufficient dosage. 1.7 What’s wrong with patches? -Relatively expensive (typically even more than pills); -More difficult to procure DIY (only via grey market means); -Generally necessitate an antiandrogen (see Section 10 “ANTIANDROGENS”); -Can result in skin irritation; -Require being applied 24/7; -Are prone to falling off; -Aren’t always consistent in their absorption (such as with heat); -Are harder to stockpile (difficult to acquire in bulk); -Often fail to exceed menopause levels even with multiple on at once. 1.8 What’s wrong with gel? -Difficult to dose accurately which leads to inconsistent levels; -Requires regular application of goop due to a relatively short half-life; -Can be messy (goopy); -Risk second-hand exposure via contact with others -Generally necessitates an antiandrogen (see Section 10 “ANTIANDROGENS”). It should be noted however that gel requires minimal supplies for self-production which is a boon in some circumstances. 1.9 What about pellets? -Generally far more expensive than any other option; -Few providers who offer them; -Dosing adjustment periods are highly spread out; -Defective pellets can cause insufficient levels; -Crushed/broken pellets can cause unexpectedly high levels; -Generally not possible to DIY them. The last point in particular means that you can only go to those few likely-expensive providers. It’s possible that this is the first time you have even heard of pellets. See the issue? 1.10 What about sprays? These are still fairly experimental so there is little to say about them, but they share pros and cons with gel. I mostly note this here so that you are aware that they exist. 1.11 Is the difference that significant? Yes. To the point that I wrote all of this so that I could repeat myself less by instead linking this. A properly dosed injection regimen is the best form of estrogen that we have for achieving monotherapy target levels. 1.12 Is this chart accurate? XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX X ___ __ __ _ X ___ X __ __ X X| __|/ _|/ _|___ __| |_ X| __|_ ___ __ X| \/ |__ ___ __ X X| _|| _| _/ -_) _| _|X| _|\ \ / '_ \_ X| |\/| / _` \ \ /_ X X|___|_| |_| \___\__|\__|X|___/_\_\ .__(_) _ X|_| |_\__,_/_\_(_) X X X / _ \ _|_| ___ ___| |_ X ___ __ __ _ X X X| (_) | ' \(_-