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version 2
This commit is contained in:
@@ -5,14 +5,14 @@ phone to ensure the optimum ASCII art experience.
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XXXXX / |___ \ XXXXX
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X_ ___ |_|_| |_| |___ \ X
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X/ |/ _ \ __) | X
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X/ |/ _ \ __) | X
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X | | |_| | |_____| X
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X |_|\___/ _____ X
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X |_|\___/ _____ X
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X / _ \ |___ / X
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X / _ \ |___ / X
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X| (_) | |_ \ X
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@@ -55,11 +55,11 @@ X /_/ |____/ X
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============================================================================
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============================================================================
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============A comprehensive FAQ/Walkthrough for Feminizing HRT==============
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============A comprehensive FAQ/Walkthrough for Feminizing HRT==============
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============================================================================
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============================================================================
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==="The Time Cube of HRT guides" - gretchen (@boxofmillipedes.bsky.social)==
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=="The Time Cube of HRT guides" - gretchen (@humanremains.northsky.social)==
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============================================================================
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============================================================================
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===================By: Katie Tightpussy (@katie.bzky.team)==================
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===================By: Katie Tightpussy (@katie.bzky.team)==================
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===========================October 8, 2025==================================
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===========================October 27, 2025=================================
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=============================Version 1.21===================================
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=============================Version 1.28===================================
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============================================================================
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============================================================================
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@@ -82,10 +82,10 @@ A Practical Guide To Feminizing HRT
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Katie Tightpussy
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Katie Tightpussy
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Helpfully modified into a 90s-00s style .txt file by gretchen
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Helpfully modified into a 90s-00s style .txt file by gretchen
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(@boxofmillipedes.bsky.social) for Gen X and Millennial readers, mostly
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(@humanremains.northsky.social) for Gen X and Millennial readers, mostly
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because I thought it'd be funny.
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because I thought it'd be funny.
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(October 8, 2025)
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(October 27, 2025)
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============================================================================
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============================================================================
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DISCLAIMER
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DISCLAIMER
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@@ -99,10 +99,64 @@ medical advice. This guide prioritizes community moral truth where scientific
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research falters. Basically, don’t get mad at me.
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research falters. Basically, don’t get mad at me.
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============================================================================
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T A B L E O F C O N T E N T S...
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============================================================================
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| Chapter | Title | CTRL+F Code |
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|---------------------------------------------------------------------------
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| 0 | FOREWARD | Alpha |
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|---------------------------------------------------------------------------
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| 0.1 | DEDICATION | Beta |
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|---------------------------------------------------------------------------
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| 1 | INTRODUCTION | Gamma |
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|---------------------------------------------------------------------------
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| 2 | WHY INJECTIONS | Delta |
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|---------------------------------------------------------------------------
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| 3 | TYPES AND DOSAGES | Epsilon |
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|---------------------------------------------------------------------------
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| 4 | BLOOD TESTS AND LEVELS | Zeta |
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|---------------------------------------------------------------------------
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| 5 | TECHNIQUE AND SUPPLIES | Eta |
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|---------------------------------------------------------------------------
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| 6 | SOURCING VIALS | Theta |
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|---------------------------------------------------------------------------
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| 7 | TROUBLESHOOTING | Iota |
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|---------------------------------------------------------------------------
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| 8 | PROGESTERONE | Kappa |
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|---------------------------------------------------------------------------
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| 9 | TESTOSTERONE | Lambda |
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|---------------------------------------------------------------------------
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| 10 | ANTIANDROGENS | Mu |
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|---------------------------------------------------------------------------
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| 11 | MYTHS AND MISCS | Nu |
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|---------------------------------------------------------------------------
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| 12 | CREATINE | Xi |
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|---------------------------------------------------------------------------
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| 13 | CLOSING REMARKS | Omicron |
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|---------------------------------------------------------------------------
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| 13.1 | FRIENDS OF PGHRT | Pi |
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|---------------------------------------------------------------------------
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| 13.2 | ABOUT THE AUTHOR | Rho |
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|---------------------------------------------------------------------------
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| 13.3 | DISCLOSURES | Sigma |
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|---------------------------------------------------------------------------
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| 13.4 | ACKNOWLEDGEMENTS | Tau |
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|---------------------------------------------------------------------------
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| 13.5 | CHEAT CODES | Upsilon |
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|---------------------------------------------------------------------------
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| 13.6 | CHANGELOG | Phi |
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============================================================================
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============================================================================
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============================================================================
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0 - FOREWORD
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0 - FOREWORD
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============================================================================
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============================================================================
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---------------------
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| CTRL+F Code = Alpha |
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---------------------
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|
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The purpose of this living document is to catalogue my thoughts and opinions
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The purpose of this living document is to catalogue my thoughts and opinions
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regarding feminizing HRT because I believe that the various community wikis
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regarding feminizing HRT because I believe that the various community wikis
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are impractical. They are valuable resources, but in my view these wikis lack
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are impractical. They are valuable resources, but in my view these wikis lack
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@@ -154,11 +208,25 @@ page/document so that you can refer back to it any time you have questions
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about your HRT. It is a lot to absorb up front, so it’s okay if it doesn’t! No
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about your HRT. It is a lot to absorb up front, so it’s okay if it doesn’t! No
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rush on any of this.
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rush on any of this.
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This document can also be downloaded as a PDF (https://pghrt.diy/pghrt.pdf).
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Please do so.
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Alternatively, you can read a modern html version if you are inclined
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(https://pghrt.diy/). It will be updated more frequently than this .txt
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version.
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If you are interested in doing a translation or any other alternate
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version, please get in touch!
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============================================================================
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============================================================================
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DEDICATION
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DEDICATION
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============================================================================
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============================================================================
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|
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---------------------
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| CTRL+F Code = Beta |
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---------------------
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|
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This document is dedicated to all of our sisters who did not make it. May we
|
This document is dedicated to all of our sisters who did not make it. May we
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carry the light of their torch into another day.
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carry the light of their torch into another day.
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@@ -167,6 +235,10 @@ carry the light of their torch into another day.
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1 - INTRODUCTION
|
1 - INTRODUCTION
|
||||||
============================================================================
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============================================================================
|
||||||
|
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||||||
|
---------------------
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||||||
|
| CTRL+F Code = Gamma |
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||||||
|
---------------------
|
||||||
|
|
||||||
1.1 Is taking estrogen safe?
|
1.1 Is taking estrogen safe?
|
||||||
|
|
||||||
With modern bioidentical hormones, HRT could not be much safer. You’re just
|
With modern bioidentical hormones, HRT could not be much safer. You’re just
|
||||||
@@ -269,7 +341,6 @@ throughout the day. Under 4mg is almost never a sufficient dosage.
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||||||
1.8 What’s wrong with gel?
|
1.8 What’s wrong with gel?
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||||||
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||||||
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||||||
-Difficult to dose accurately which leads to inconsistent levels;
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-Difficult to dose accurately which leads to inconsistent levels;
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||||||
|
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||||||
-Requires regular application of goop due to a relatively short half-life;
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-Requires regular application of goop due to a relatively short half-life;
|
||||||
@@ -317,10 +388,73 @@ by instead linking this. A properly dosed injection regimen is the best form
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of estrogen that we have for achieving monotherapy target levels.
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of estrogen that we have for achieving monotherapy target levels.
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1.12 Is this chart accurate?
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XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
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X ___ __ __ _ X ___ X __ __ X
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X| __|/ _|/ _|___ __| |_ X| __|_ ___ __ X| \/ |__ ___ __ X
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X| _|| _| _/ -_) _| _|X| _|\ \ / '_ \_ X| |\/| / _` \ \ /_ X
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X|___|_| |_| \___\__|\__|X|___/_\_\ .__(_) _ X|_| |_\__,_/_\_(_) X
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X X / _ \ _|_| ___ ___| |_ X ___ __ __ _ X
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X X| (_) | ' \(_-</ -_) _|X| __|/ _|/ _|___ __| |_ X
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X X \___/|_||_/__/\___|\__|X| _|| _| _/ -_) _| _|X
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X X X|___|_| |_| \___\__|\__|X
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XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
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X X X X
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X Decreased Boners X Imminent X Inverse Priapism X
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X X X X
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XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
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X X X X
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X Translucent Skin X 3 - 16 Weeks X Everyone can just see X
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X X X all your organs and X
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X X X shit. It's nasty, X
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X X X dude. X
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X X X X
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XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
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X X X X
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X Breastile Deployment X Varies, depending on X Exponential Growth X
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X X planetary alignments. X X
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X X X X
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||||||
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XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
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X X X X
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X Pee X Stored in the Balls X Fact checked by Real X
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X X X American Patriots X
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X X X Verdict: TRUE X
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X X X X
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XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
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Figure 0: This Chart Sucks [gretchen's note: mine rules, actually]
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||||||
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||||||
|
No. While this guide is not interested in playing whackamole by responding
|
||||||
|
directly to every instance of misinformation on social media, the prevalence
|
||||||
|
of this chart both online and in doctor-provided resources across languages
|
||||||
|
paired with the sheer volume of harm it has caused denotes need for special
|
||||||
|
exception beyond off-hand reference in Question 11.6.
|
||||||
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|
||||||
|
This chart is categorically false. Nearly every aspect of it is misleading in
|
||||||
|
some capacity, with the one exception being that it is wholly true that
|
||||||
|
estrogen does not cause vocal changes. The time ranges listed for “expected
|
||||||
|
onset” are misleading, and the idea of a time limit for “maximum effect” is
|
||||||
|
so misleading that it borders on criminal. A plethora of changes are not
|
||||||
|
listed (such as mental effects) or are wrong (the chart contradicts itself
|
||||||
|
about erectile dysfunction). No consideration is given towards regimen quality
|
||||||
|
either. The key aspects of the chart requiring nuance are discussed across
|
||||||
|
this guide, so the only general takeaway should be that change happens at
|
||||||
|
different rates. This chart causes poor expectations, provides an inaccurate
|
||||||
|
picture of what HRT does, and sets trans people up for failure by limiting
|
||||||
|
their understanding of hormones. Please disregard it in its entirety. Except
|
||||||
|
for the part about pee. That part is true. Pee is stored in the balls.
|
||||||
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|
||||||
|
Now, let us continue after this detour.
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||||||
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||||||
|
|
||||||
============================================================================
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============================================================================
|
||||||
2 - WHY INJECTIONS
|
2 - WHY INJECTIONS
|
||||||
============================================================================
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============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Delta |
|
||||||
|
---------------------
|
||||||
|
|
||||||
2.1 What makes injections so good?
|
2.1 What makes injections so good?
|
||||||
|
|
||||||
@@ -345,10 +479,11 @@ it has enough. If there are consistently enough hormones in your body, it
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|||||||
stops producing more. The “consistent” part is what injections are capable of
|
stops producing more. The “consistent” part is what injections are capable of
|
||||||
that other administration routes struggle with. Trying to do sufficient
|
that other administration routes struggle with. Trying to do sufficient
|
||||||
monotherapy on pills, for instance, is very likely impossible in most
|
monotherapy on pills, for instance, is very likely impossible in most
|
||||||
situations. In more specific terms regarding the HPG axis, luteinizing hormone
|
situations. In more specific terms regarding the HPG axis
|
||||||
(LH) and follicle-stimulating hormone (FSH) are suppressed by increased serum
|
(https://en.wikipedia.org/wiki/Hypothalamic-pituitary-gonadal_axis),
|
||||||
estradiol levels, thus inhibiting GnRH production and by extension
|
luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are suppressed
|
||||||
testosterone production in the testes.
|
by increased serum estradiol levels, thus inhibiting GnRH production and by
|
||||||
|
extension testosterone production in the testes.
|
||||||
|
|
||||||
|
|
||||||
2.4 How are injections safer?
|
2.4 How are injections safer?
|
||||||
@@ -402,6 +537,12 @@ from increased breast development, improved mental health, alleviated side
|
|||||||
effects of antiandrogens or other forms of estrogen, generally feeling better,
|
effects of antiandrogens or other forms of estrogen, generally feeling better,
|
||||||
etc. Switching is worth it.
|
etc. Switching is worth it.
|
||||||
|
|
||||||
|
It should be noted that time on HRT before injections is not
|
||||||
|
”wasted”, nor is there a limited window that estrogen is most ef-
|
||||||
|
fective for feminization. It is the consistency of injections that makes them
|
||||||
|
as good as they are, but the destination will be largely the same either way.
|
||||||
|
See Questions 11.5 and 11.6.
|
||||||
|
|
||||||
|
|
||||||
2.10 But injections are scary?
|
2.10 But injections are scary?
|
||||||
|
|
||||||
@@ -445,6 +586,9 @@ mind, this guide will still be here. And if you don’t, so be it
|
|||||||
3 - TYPES AND DOSAGES
|
3 - TYPES AND DOSAGES
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
-----------------------
|
||||||
|
| CTRL+F Code = Epsilon |
|
||||||
|
-----------------------
|
||||||
|
|
||||||
Key Vocabulary
|
Key Vocabulary
|
||||||
|
|
||||||
@@ -513,10 +657,8 @@ everything HRT-related that you are taking and at what frequencies.
|
|||||||
Your dosage is the concentration of your vial multiplied by the volume that
|
Your dosage is the concentration of your vial multiplied by the volume that
|
||||||
you are injecting.
|
you are injecting.
|
||||||
|
|
||||||
|
|
||||||
Concentration(mg/ml)∗volume(ml)=dosage(mg)
|
Concentration(mg/ml)∗volume(ml)=dosage(mg)
|
||||||
|
|
||||||
|
|
||||||
Please understand that volume alone is not a dosage. An analogy would be with
|
Please understand that volume alone is not a dosage. An analogy would be with
|
||||||
baking: you cannot just say “bake for 45 minutes” because you have to know
|
baking: you cannot just say “bake for 45 minutes” because you have to know
|
||||||
what temperature to set the oven.
|
what temperature to set the oven.
|
||||||
@@ -563,6 +705,12 @@ comparisons between them, but there is no method to convert one to another.
|
|||||||
|
|
||||||
3.10 How can I compare different curves and dosages between esters?
|
3.10 How can I compare different curves and dosages between esters?
|
||||||
|
|
||||||
|
If you would like to get nerdy, I rate estrannai.se (http://estrannai.se/)
|
||||||
|
quite highly. Keep in mindthat this isn’t required but it is a good tool for
|
||||||
|
performing rough comparisons. Here
|
||||||
|
(https://estrannai.se/#i0__cu,7,7,1-cu,5,7,3-cu,5,7,2) is an example
|
||||||
|
comparison between typical weekly dosages which we will now see individually.
|
||||||
|
|
||||||
It should be noted that the dosages I list below should be sufficient on the
|
It should be noted that the dosages I list below should be sufficient on the
|
||||||
lower end of the range in most cases. Start with the lower number and move up
|
lower end of the range in most cases. Start with the lower number and move up
|
||||||
if you need. More is not inherently better, but we will discuss that in depth
|
if you need. More is not inherently better, but we will discuss that in depth
|
||||||
@@ -731,6 +879,10 @@ Figure 4: The Moon
|
|||||||
4 - BLOOD TESTS AND LEVELS
|
4 - BLOOD TESTS AND LEVELS
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Zeta |
|
||||||
|
---------------------
|
||||||
|
|
||||||
Acquiring Results
|
Acquiring Results
|
||||||
|
|
||||||
4.1 How often should I test my levels?
|
4.1 How often should I test my levels?
|
||||||
@@ -903,6 +1055,10 @@ or whatever else. It’s all estrogen at the end of the day.
|
|||||||
5 - TECHNIQUE AND SUPPLIES
|
5 - TECHNIQUE AND SUPPLIES
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Eta |
|
||||||
|
---------------------
|
||||||
|
|
||||||
Sites & Safety
|
Sites & Safety
|
||||||
|
|
||||||
5.1 How do I safely perform an injection?
|
5.1 How do I safely perform an injection?
|
||||||
@@ -1142,12 +1298,13 @@ myself?
|
|||||||
|
|
||||||
You might like an auto-injector. As the name suggests, auto-injectors perform
|
You might like an auto-injector. As the name suggests, auto-injectors perform
|
||||||
the injection for you. Auto-injectors like the UnionMedico 45/90 Super Grip
|
the injection for you. Auto-injectors like the UnionMedico 45/90 Super Grip
|
||||||
can take 1ml syringes which can take the difficulty out of injecting (but you
|
(https://unionmedico.com/90-super-grip/) can take 1ml syringes which can take
|
||||||
still manually press the plunger), whereas auto-injectors like the Owen
|
the difficulty out of injecting (but you still manually press the plunger),
|
||||||
Mumford Autoject 2 entirely hide the needle of an insulin syringe and
|
whereas auto-injectors like the Owen Mumford Autoject 2
|
||||||
automatically push down the plunger. There are also a variety of 3D printable
|
(https://www.owenmumford.com/us/medical-devices/autoject-2) entirely hide the
|
||||||
designs available online. I have used none of these products and these are not
|
needle of an insulin syringe and automatically push down the plunger. There
|
||||||
endorsements.
|
are also a variety of 3D printable designs available online. I have used none
|
||||||
|
of these products and these are not endorsements.
|
||||||
|
|
||||||
|
|
||||||
Basics of a Vial
|
Basics of a Vial
|
||||||
@@ -1235,6 +1392,10 @@ you can go here (https://safeneedledisposal.org/).
|
|||||||
6 - SOURCING VIALS
|
6 - SOURCING VIALS
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Theta |
|
||||||
|
---------------------
|
||||||
|
|
||||||
6.1 Where do I get estrogen vials to inject?
|
6.1 Where do I get estrogen vials to inject?
|
||||||
|
|
||||||
Broadly speaking, you have two options: pharmaceutical sources and DIY
|
Broadly speaking, you have two options: pharmaceutical sources and DIY
|
||||||
@@ -1288,9 +1449,9 @@ Pharmaceutical Sourcing
|
|||||||
|
|
||||||
-Harder to stockpile;
|
-Harder to stockpile;
|
||||||
|
|
||||||
Access is subject to the whims of your country’s political situation which
|
-Access is subject to the whims of your country’s political situation
|
||||||
also means that your transness will likely be included on your medical
|
which also means that your transness will likely be included on your
|
||||||
record.
|
medical record.
|
||||||
|
|
||||||
|
|
||||||
DIY Sourcing
|
DIY Sourcing
|
||||||
@@ -1312,6 +1473,7 @@ DIY Sourcing
|
|||||||
|
|
||||||
-It’s probably made with love.
|
-It’s probably made with love.
|
||||||
|
|
||||||
|
|
||||||
6.6 What are the cons of DIY sources?
|
6.6 What are the cons of DIY sources?
|
||||||
|
|
||||||
-Almost certainly not made in a certified clean room;
|
-Almost certainly not made in a certified clean room;
|
||||||
@@ -1487,10 +1649,15 @@ recommended for batch consistency and in many cases is necessary depending on
|
|||||||
the carrier oil and the desired concentration. Some people find it irritating,
|
the carrier oil and the desired concentration. Some people find it irritating,
|
||||||
but others don’t.
|
but others don’t.
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
7 - TROUBLESHOOTING
|
7 - TROUBLESHOOTING
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Iota |
|
||||||
|
---------------------
|
||||||
|
|
||||||
Dosage Uncertainty
|
Dosage Uncertainty
|
||||||
|
|
||||||
7.1 My levels aren’t what I expected them to be. Why not?
|
7.1 My levels aren’t what I expected them to be. Why not?
|
||||||
@@ -1570,7 +1737,9 @@ No. Leakage can happen for any number of reasons and is rarely enough to make
|
|||||||
a difference, so you do not need to do another injection. For the future, make
|
a difference, so you do not need to do another injection. For the future, make
|
||||||
sure to leave the needle in for 5-10 seconds before retracting and then apply
|
sure to leave the needle in for 5-10 seconds before retracting and then apply
|
||||||
pressure afterwards. You might consider using the air lock technique mentioned
|
pressure afterwards. You might consider using the air lock technique mentioned
|
||||||
above if you are particularly concerned about leakage.
|
above or the Z-track method
|
||||||
|
(https://www.nurse.com/nursing-resources/definitions/what-is-z-track-method/)
|
||||||
|
if you are particularly concerned about leakage.
|
||||||
|
|
||||||
|
|
||||||
7.9 Sometimes I am really sore after an injection. Will I die?
|
7.9 Sometimes I am really sore after an injection. Will I die?
|
||||||
@@ -1604,10 +1773,15 @@ contents have separated entirely. With a lot more heat and stirring the
|
|||||||
crystals might reincorporate, but it is simplest and safest to replace the
|
crystals might reincorporate, but it is simplest and safest to replace the
|
||||||
vial if you can.
|
vial if you can.
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
8 - PROGESTERONE
|
8 - PROGESTERONE
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Kappa |
|
||||||
|
---------------------
|
||||||
|
|
||||||
8.1 Do I want to take progesterone?
|
8.1 Do I want to take progesterone?
|
||||||
|
|
||||||
Probably. This is a controversial question for some reason. Detractors
|
Probably. This is a controversial question for some reason. Detractors
|
||||||
@@ -1804,10 +1978,15 @@ It is recommended to not take either of those if you are someone affected by
|
|||||||
this interaction, but it is not in all cases anyway. Note that these
|
this interaction, but it is not in all cases anyway. Note that these
|
||||||
depressive effects may be felt for up to a month after stopping.
|
depressive effects may be felt for up to a month after stopping.
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
9 - TESTOSTERONE
|
9 - TESTOSTERONE
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Lambda |
|
||||||
|
---------------------
|
||||||
|
|
||||||
9.1 Why don’t we want zero testosterone?
|
9.1 Why don’t we want zero testosterone?
|
||||||
|
|
||||||
Testosterone is an essential sex hormone which plays a key role in your health
|
Testosterone is an essential sex hormone which plays a key role in your health
|
||||||
@@ -1872,7 +2051,7 @@ feel.
|
|||||||
|
|
||||||
If you are an American, you would have to get a prescription or ask any juicer
|
If you are an American, you would have to get a prescription or ask any juicer
|
||||||
at your closest Planet Fitness. Elsewhere, it depends on what gym chain is
|
at your closest Planet Fitness. Elsewhere, it depends on what gym chain is
|
||||||
closest to you. Disclaimer: This is a joke. See Question 6.11 “Is DIY legal?”
|
closest to you. Disclaimer: This is a joke. See Question 6.11.
|
||||||
|
|
||||||
|
|
||||||
9.8 Are other steroids equivalent to testosterone in an HRT context?
|
9.8 Are other steroids equivalent to testosterone in an HRT context?
|
||||||
@@ -1911,10 +2090,15 @@ how dihydrotestosterone cream is useful when a patient doesn’t respond to
|
|||||||
testosterone (particularly in the case of 5α-Reductase deficiencies). So,
|
testosterone (particularly in the case of 5α-Reductase deficiencies). So,
|
||||||
food for thought. Someone get Oliver Longdick to handle the rest of this.
|
food for thought. Someone get Oliver Longdick to handle the rest of this.
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
10 - ANTIANDROGENS
|
10 - ANTIANDROGENS
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Mu |
|
||||||
|
---------------------
|
||||||
|
|
||||||
10.1 What are “antiandrogens”?
|
10.1 What are “antiandrogens”?
|
||||||
|
|
||||||
Antiandrogens, commonly also referred to as “T blockers” or just “blockers”,
|
Antiandrogens, commonly also referred to as “T blockers” or just “blockers”,
|
||||||
@@ -2044,10 +2228,15 @@ simply pharmacies in another country, although these often take some hurdles
|
|||||||
to purchase from. Dutasteride and finasteride are generally the easiest to get
|
to purchase from. Dutasteride and finasteride are generally the easiest to get
|
||||||
over-the-counter because of their commonality as hair loss medication.
|
over-the-counter because of their commonality as hair loss medication.
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
11 - MYTHS AND MISCS
|
11 - MYTHS AND MISCS
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Nu |
|
||||||
|
---------------------
|
||||||
|
|
||||||
Common Questions
|
Common Questions
|
||||||
|
|
||||||
11.1 Should I be worried about blood clots?
|
11.1 Should I be worried about blood clots?
|
||||||
@@ -2071,7 +2260,8 @@ still include it in their pre-surgery guidelines out of concern for blood
|
|||||||
clots, but this is torture that has been disproven and even WPATH doesn’t
|
clots, but this is torture that has been disproven and even WPATH doesn’t
|
||||||
recommend it anymore. Remarkable, I know.
|
recommend it anymore. Remarkable, I know.
|
||||||
|
|
||||||
Per WPATH SOC 8 Statement 12.19:
|
Per WPATH SOC 8 Statement 12.19
|
||||||
|
(https://www.tandfonline.com/doi/pdf/10.1080/26895269.2022.2100644):
|
||||||
|
|
||||||
"After careful examination, investigators have found no perioperative
|
"After careful examination, investigators have found no perioperative
|
||||||
increase in the rate of VTE [KT: venous thromboembolism, i.e. a blood
|
increase in the rate of VTE [KT: venous thromboembolism, i.e. a blood
|
||||||
@@ -2321,7 +2511,10 @@ Aside from using it regularly, ways to improve erectile function include:
|
|||||||
1) Improving your fitness and physical health, particularly your
|
1) Improving your fitness and physical health, particularly your
|
||||||
cardiovascular ability; 2) consider medication like tadalafil or sildenafil;
|
cardiovascular ability; 2) consider medication like tadalafil or sildenafil;
|
||||||
and 3) consider testosterone supplementation (see Section 9 “TESTOSTERONE”).
|
and 3) consider testosterone supplementation (see Section 9 “TESTOSTERONE”).
|
||||||
|
If you would like to read a longer explanation for how erectile function
|
||||||
|
works, this Substack article
|
||||||
|
(https://stainedglasswoman.substack.com/p/how-to-maintain-your-penis-function)
|
||||||
|
provides a good overview of the topic.
|
||||||
|
|
||||||
11.21 How do I increase cum/pre-cum volume on HRT?
|
11.21 How do I increase cum/pre-cum volume on HRT?
|
||||||
|
|
||||||
@@ -2362,7 +2555,23 @@ that is chemical or behavioral. A matter of perspective.
|
|||||||
|
|
||||||
11.25 Should I be on PrEP?
|
11.25 Should I be on PrEP?
|
||||||
|
|
||||||
Yes.
|
Yes. Pre-exposure prophylaxis for HIV prevention (PrEP)
|
||||||
|
(https://en.wikipedia.org/wiki/Pre-exposure_prophylaxis_for_HIV_prevention) is
|
||||||
|
a category of antiviral drugs for the purpose of preventing HIV/AIDS. This is
|
||||||
|
not directly related to HRT, but it is common for trans women to be at
|
||||||
|
elevated risk of HIV/AIDs. Given the history of the AIDS pandemic, PrEP is a
|
||||||
|
miracle of modern medicine that should interest you. Note: There is no effect
|
||||||
|
of any PrEP drug on HRT so you are encouraged to be on PrEP. If you are
|
||||||
|
sexually active, you should strongly consider being on PrEP. Even if you are
|
||||||
|
not sexually active, trans women are at a significantly higher risk of sexual
|
||||||
|
violence, so you should still strongly consider being on PrEP. In most places
|
||||||
|
you are likely to be prescribed Truvada as a once-daily pill, although if you
|
||||||
|
experience nausea as a side effect you can likely swap to Descovy with no
|
||||||
|
change in effectiveness. In the US, insurance commonly does not cover Descovy
|
||||||
|
unless you have tried or say you have tried Truvada. The novel drug
|
||||||
|
lenacapavir as a twice-yearly injection is expected to make PrEP significantly
|
||||||
|
easier as access becomes more widely available, if current options are
|
||||||
|
prohibitive for you.
|
||||||
|
|
||||||
|
|
||||||
Medical Malpractice
|
Medical Malpractice
|
||||||
@@ -2509,7 +2718,7 @@ You’re on your own if that’s something you want to explore, so please be saf
|
|||||||
I don’t personally rate them very highly as I have not seen much to suggest
|
I don’t personally rate them very highly as I have not seen much to suggest
|
||||||
that they work well for how people usually think or want them to work, at
|
that they work well for how people usually think or want them to work, at
|
||||||
least not without a lot more caveats, but obviously there are people who like
|
least not without a lot more caveats, but obviously there are people who like
|
||||||
them. It’s just not something I feel comfortable giving recommendations for.
|
them. It’s just not something I feel comfortable giving recommendations for.
|
||||||
|
|
||||||
The various proposed nonbinary regimens are often highly individualized
|
The various proposed nonbinary regimens are often highly individualized
|
||||||
because they are specific to what a persons’ particular goals are. All HRT
|
because they are specific to what a persons’ particular goals are. All HRT
|
||||||
@@ -2525,11 +2734,11 @@ goals than just hormones alone.
|
|||||||
|
|
||||||
No. If someone is telling you they have “herbal HRT”, they are telling you
|
No. If someone is telling you they have “herbal HRT”, they are telling you
|
||||||
they have snake oil. The only thing that is going to feminize you is estrogen,
|
they have snake oil. The only thing that is going to feminize you is estrogen,
|
||||||
not plant estrogens. No amount of “natural” products are a replacement for
|
not plant estrogens. No amount of “natural” products are a replacement for
|
||||||
estrogen itself. This isn’t a common scam and you probably already know, but
|
estrogen itself. This isn’t a common scam and you probably already know, but
|
||||||
just in case you run into it, now you know for sure. If it smells like
|
just in case you run into it, now you know for sure. If it smells like
|
||||||
bullshit, it’s probably bullshit. Unless we’re talking about bug steroids in
|
bullshit, it’s probably bullshit. Unless we’re talking about bug steroids in
|
||||||
which case yeah those are actually cool. Won’t feminize you though.
|
which case yeah those are actually cool. Won’t feminize you though.
|
||||||
|
|
||||||
|
|
||||||
11.40 Is the Reddit Doctor that people constantly talk about good?
|
11.40 Is the Reddit Doctor that people constantly talk about good?
|
||||||
@@ -2546,10 +2755,50 @@ what you could even theoretically do with a bathtub, unless you think estrogen
|
|||||||
vials are full of the bathwater of trans women. I don’t know why you would
|
vials are full of the bathwater of trans women. I don’t know why you would
|
||||||
think that though. It’s obviously cum.
|
think that though. It’s obviously cum.
|
||||||
|
|
||||||
|
|
||||||
|
11.42 How does HRT affect fertility?
|
||||||
|
|
||||||
|
It is important to understand that this is extremely understudied so exact
|
||||||
|
figures cannot be stated, and given the seriousness of pregnancy, I urge you
|
||||||
|
to practice safe sex and lean on the side of caution where possible. HRT
|
||||||
|
itself can, and likely will, make you infertile eventually, but only through
|
||||||
|
full suppression ofthe HPG axis (See Question 2.3) over a long time span. In
|
||||||
|
other words, if you haven’t had bottom surgery of any kind and you are on an
|
||||||
|
HRT regimen that is less capable of HPG axis suppression (such as pills), then
|
||||||
|
this is more of a consideration.
|
||||||
|
|
||||||
|
If the HPG axis is not suppressed then it is fully possible to impregnate
|
||||||
|
someone, and the timeline for sperm maturation is long enough that this is
|
||||||
|
true even after the HPG axis has been initially suppressed for multiple
|
||||||
|
months. Please take this very seriously. Full HPG axis suppression for at
|
||||||
|
minimum six months, perhaps closer to a year out of an abundance of caution,
|
||||||
|
is recommended.
|
||||||
|
|
||||||
|
|
||||||
|
11.43 Is infertility from HRT reversible?
|
||||||
|
|
||||||
|
It is theoretically possible to reverse HRT-induced infertility, assuming you
|
||||||
|
weren’t already infertile prior to HRT (a large assumption!), but there are
|
||||||
|
not many documented cases of this so the full efficacy of fertility
|
||||||
|
restoration after long-term HRT is unknown. The process would involve
|
||||||
|
restarting the HPG axis with a variety of medications along with entirely
|
||||||
|
stopping HRT, which would in essence require a hormonal detransition for
|
||||||
|
likely six months at minimum, and even then sperm quality is not certain or
|
||||||
|
guaranteed. It is not something that should be planned for, to say the least,
|
||||||
|
so planning around it would be wise. A sperm bank would be recommended before
|
||||||
|
or early in HRT, financially permitting, if potential biological children are
|
||||||
|
a priority and if a future relationship where that is possible/desired is
|
||||||
|
likely.
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
12 - CREATINE [gretchen's note: oh for fuck's sake]
|
12 - CREATINE [gretchen's note: oh for fuck's sake]
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Xi |
|
||||||
|
---------------------
|
||||||
|
|
||||||
12.1 What is creatine?
|
12.1 What is creatine?
|
||||||
|
|
||||||
Creatine is an organic compound in your muscles and in your brain. It recycles
|
Creatine is an organic compound in your muscles and in your brain. It recycles
|
||||||
@@ -2656,6 +2905,10 @@ talking about it!!!
|
|||||||
13 - CLOSING REMARKS
|
13 - CLOSING REMARKS
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
-----------------------
|
||||||
|
| CTRL+F Code = Omicron |
|
||||||
|
-----------------------
|
||||||
|
|
||||||
If any of the following are true:
|
If any of the following are true:
|
||||||
|
|
||||||
-you are still mad at me despite the disclaimer;
|
-you are still mad at me despite the disclaimer;
|
||||||
@@ -2687,10 +2940,63 @@ your presence is a blessing on those around you, and that you deserve to be
|
|||||||
treated with respect. Even if you do nothing else, your life is a feat worth
|
treated with respect. Even if you do nothing else, your life is a feat worth
|
||||||
praising. Thank you.
|
praising. Thank you.
|
||||||
|
|
||||||
|
|
||||||
|
============================================================================
|
||||||
|
FRIENDS OF PGHRT
|
||||||
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Pi |
|
||||||
|
---------------------
|
||||||
|
|
||||||
|
Across this document is a scattering of links to other guides and resources.
|
||||||
|
Below is a consolidation of them which will also include more links to external
|
||||||
|
resources as time goes on, ideally by other trans people. For the privacy minded
|
||||||
|
or noided, note that some of these are Google Docs links.
|
||||||
|
|
||||||
|
1. SW4EEWATAOTTM - TL;DR for PGHRT
|
||||||
|
(https://startwith4mgestradiolenanthateweeklyandtestatonetothreemonths.com/)
|
||||||
|
|
||||||
|
2. HRT Cafe - HRT Resource Aggregator
|
||||||
|
(https://hrtcafe.net/)
|
||||||
|
|
||||||
|
3. Transfeminine Science - Informational resource for trans medical literature
|
||||||
|
(https://transfemscience.org/)
|
||||||
|
|
||||||
|
4. Estrannai.se - Estradiol Pharmacokinetics Playground
|
||||||
|
(http://estrannai.se/)
|
||||||
|
|
||||||
|
5. Globoho.moe - Thailand Orchiectomy Medical Tourism Travel Guide
|
||||||
|
(https://globoho.moe/)
|
||||||
|
|
||||||
|
6. Julia’s FUE Guide - COMING SOON, I’M BULLYING HER TO WRITE FASTER
|
||||||
|
|
||||||
|
7. Sky’s Feminine Figure Beginner Program - An exercise regimen geared
|
||||||
|
towards trans fems
|
||||||
|
(https://docs.google.com/document/d/
|
||||||
|
1-NyE5EY5TTaRRMhk7HlTbKJ7HifjEsA4jlDO1qKQVl0/edit?tab=t.0)
|
||||||
|
|
||||||
|
8. Sky’s Diet 101 - A guide towards adjusting weight in a healthy way
|
||||||
|
(https://docs.google.com/document/d/
|
||||||
|
114sztSw1aVWM2pXLDl9NrHklyvewz3EmFiHiisjM71k/edit?tab=t.0)
|
||||||
|
|
||||||
|
9. How to Maintain Erectile Function on HRT - A longer form explanation on the
|
||||||
|
”use it or lose it” phenomenon
|
||||||
|
(https://stainedglasswoman.substack.com/p/how-to-maintain-your-penis-function)
|
||||||
|
|
||||||
|
10. Biohax Guide Googleslop Edition - Trans Masc DIY Guide
|
||||||
|
(https://docs.google.com/document/d/
|
||||||
|
1DXFxzN0XTudPZez_SO61fpqncRLPH_Be_QG_8Pcz9LU/edit?pli=1&tab=t.0)
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
ABOUT THE AUTHOR
|
ABOUT THE AUTHOR
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Rho |
|
||||||
|
---------------------
|
||||||
|
|
||||||
Katie Tightpussy is an award-winning author and professional trans woman with
|
Katie Tightpussy is an award-winning author and professional trans woman with
|
||||||
nearly a decade of experience in the field of transgender. Her accomplishments
|
nearly a decade of experience in the field of transgender. Her accomplishments
|
||||||
include transiferating her sex through the novel technique of cross-sex hormone
|
include transiferating her sex through the novel technique of cross-sex hormone
|
||||||
@@ -2698,12 +3004,18 @@ injections, being physically unable to shut up, and utilizing a very fortunate
|
|||||||
set of hyperfixations as they relate to transbobulation of the humors. She
|
set of hyperfixations as they relate to transbobulation of the humors. She
|
||||||
spends her days in the idyllic rural countryside of Los Angeles scheming of
|
spends her days in the idyllic rural countryside of Los Angeles scheming of
|
||||||
new ways to achieve world domination and enjoys riding her bicycle. Media
|
new ways to achieve world domination and enjoys riding her bicycle. Media
|
||||||
inquiries can reach her agent at katietightpussy.com.
|
inquiries can reach her agent at katietightpussy.com
|
||||||
|
(http://katietightpussy.com/).
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
DISCLOSURES
|
DISCLOSURES
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
---------------------
|
||||||
|
| CTRL+F Code = Sigma |
|
||||||
|
---------------------
|
||||||
|
|
||||||
No robot girls were harmed in the making of this document, including any
|
No robot girls were harmed in the making of this document, including any
|
||||||
usage of generative large language models. The author does not endorse any
|
usage of generative large language models. The author does not endorse any
|
||||||
reproduction without attribution nor scraping of this work. Leave those poor
|
reproduction without attribution nor scraping of this work. Leave those poor
|
||||||
@@ -2713,10 +3025,15 @@ The author declares an attraction towards women and acknowledges a potential
|
|||||||
conflict of interest for the existence of more beautiful trans women in the
|
conflict of interest for the existence of more beautiful trans women in the
|
||||||
world.
|
world.
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
ACKNOWLEDGEMENTS
|
ACKNOWLEDGEMENTS
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
|
--------------------
|
||||||
|
| CTRL+F Code = Tau |
|
||||||
|
--------------------
|
||||||
|
|
||||||
Though the text is primarily my voice, this document would not be even half
|
Though the text is primarily my voice, this document would not be even half
|
||||||
as good without the contributions, feedback, and suggestions from others
|
as good without the contributions, feedback, and suggestions from others
|
||||||
involved at every step along the way. A good reminder as ever that transition
|
involved at every step along the way. A good reminder as ever that transition
|
||||||
@@ -2727,26 +3044,37 @@ generally being fun nerds to talk to; love y’all. Special thanks to CB and J
|
|||||||
for close review that also inspired some very good bits. Thanks to KG for
|
for close review that also inspired some very good bits. Thanks to KG for
|
||||||
additional intersex information. Thanks to w [sic] for additional injection
|
additional intersex information. Thanks to w [sic] for additional injection
|
||||||
resources. Thanks to BIR collectively for a plethora of crucial nerd nitpicks.
|
resources. Thanks to BIR collectively for a plethora of crucial nerd nitpicks.
|
||||||
Appreciation for general review from C, JTP, K, S, and V. Thanks to everyone
|
Appreciation for general review from C, JTP, K, S, and V. Thanks to E for web
|
||||||
on Bluesky who encouraged me to write this up in the first place, and everyone
|
dev assistance. Thanks to everyone on Bluesky who encouraged me to write this
|
||||||
over the years sharing knowledge. And of course: much appreciation to all HRT
|
up in the first place, and everyone over the years sharing knowledge. And of
|
||||||
nerds, even when we disagree, since we’re all trying to do the best for our
|
course: much appreciation to all HRT nerds, even when we disagree, since we’re
|
||||||
community where we’ve otherwise been let down. Keep up the good work everyone.
|
all trying to do the best for our community where we’ve otherwise been let
|
||||||
|
down. Keep up the good work everyone.
|
||||||
|
|
||||||
Shout out to my IB Chemistry HL teacher many years ago who quite reasonably
|
Shout out to my IB Chemistry HL teacher many years ago who quite reasonably
|
||||||
doubted my studiousness even though I’m now putting much of that knowledge
|
doubted my studiousness even though I’m now putting much of that knowledge
|
||||||
to use for the art of transsexuality; go figure.
|
to use for the art of transsexuality; go figure.
|
||||||
|
|
||||||
|
|
||||||
|
============================================================================
|
||||||
|
CHEAT CODES
|
||||||
|
============================================================================
|
||||||
|
|
||||||
|
-----------------------
|
||||||
|
| CTRL+F Code = Upsilon |
|
||||||
|
-----------------------
|
||||||
|
|
||||||
|
You will find no cheat codes here. Cheat codes are inherently sinful and you
|
||||||
|
should be ashamed of yourself for reading this section of the guide.
|
||||||
|
|
||||||
|
|
||||||
============================================================================
|
============================================================================
|
||||||
CHANGELOG
|
CHANGELOG
|
||||||
============================================================================
|
============================================================================
|
||||||
|
|
||||||
Full Compilation Datetime: \DTMnow
|
--------------------
|
||||||
|
| CTRL+F Code = Phi |
|
||||||
(There aren’t LaTeXML bindings for datetime2 so this is only for versioning
|
--------------------
|
||||||
the PDF. For the webpage, look at the bottom of your screen silly. There
|
|
||||||
aren’t bindings for hanging or hyphenat either, so the formatting is slightly
|
|
||||||
ugly. My life is so hard.)
|
|
||||||
|
|
||||||
2025-08-20: Initial release. 15.9k words.
|
2025-08-20: Initial release. 15.9k words.
|
||||||
|
|
||||||
@@ -2778,7 +3106,8 @@ words.
|
|||||||
|
|
||||||
2025-09-23: A wide variety of clarifications up and down the line. 18.1k words.
|
2025-09-23: A wide variety of clarifications up and down the line. 18.1k words.
|
||||||
|
|
||||||
2025-09-24: Added an important note about surgery to Question 11.1. 18.3k words.
|
2025-09-24: Added an important note about surgery to Question 11.1. 18.3k
|
||||||
|
words.
|
||||||
|
|
||||||
2025-09-24: “Katie my doctor told me-” It never ends. 18.5k words.
|
2025-09-24: “Katie my doctor told me-” It never ends. 18.5k words.
|
||||||
|
|
||||||
@@ -2792,4 +3121,24 @@ Sorry that I don’t. I thought I’d be done by now anyway! 18.7k words.
|
|||||||
2025-10-02: Added a big bold warning about recapping to Question 5.13 because
|
2025-10-02: Added a big bold warning about recapping to Question 5.13 because
|
||||||
SOMEONE didn’t watch the video smh. 18.9k words.
|
SOMEONE didn’t watch the video smh. 18.9k words.
|
||||||
|
|
||||||
2025-10-08: .txt version done. Deal with it. 19.4k words.
|
2025-10-10: Added Question 11.42 and Question 11.43 per request. Honestly I
|
||||||
|
just forgot about fertility being a thing lol. Also added the Friends Of PGHRT
|
||||||
|
postword section. 19.5k words.
|
||||||
|
|
||||||
|
2025-10-10: Added gretchen’s version (.txt) and fixed formatting. 19.5k words.
|
||||||
|
|
||||||
|
2025-10-11: Added permalinks to everything, yay! And finally made a git repo.
|
||||||
|
Look at me being a big girl, wow. 19.5k words.
|
||||||
|
|
||||||
|
2025-10-11: Added an external link to Question 11.20. 19.6k words.
|
||||||
|
|
||||||
|
2025-10-14: Reduced the pithiness and expanded the usefulness of Question
|
||||||
|
11.25 per repeat request because I guess there is public health utility to
|
||||||
|
doing so. 19.8k words.
|
||||||
|
|
||||||
|
2025-10-17: Dark mode! And a font toggle off. Plus a few links. 19.8k words.
|
||||||
|
|
||||||
|
2025-10-25: A variety of micro tweaks and the inclusion of Question 1.12.
|
||||||
|
20.2k words.
|
||||||
|
|
||||||
|
2025-10-27: gretchen's updated version. 21.1k words.
|
||||||
Reference in New Issue
Block a user