In simple terms, the brain does not care which hormone it has, just as long as it has enough. If there are consistently enough hormones in your body, it stops producing more. The “consistent” part is what injections are capable of that other administration routes struggle with. Trying to do sufficient monotherapy on pills, for instance, is very likely impossible in most situations. In more specific terms regarding the HPG axis, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are suppressed by increased serum estradiol levels, thus inhibiting GnRH production and by extension testosterone production in the testes.
+In simple terms, the brain does not care which hormone it has, just as long as it has enough. If there are consistently enough hormones in your body, it stops producing more. The “consistent” part is what injections are capable of that other administration routes struggle with. Trying to do sufficient monotherapy on pills, for instance, is very likely impossible in most situations. In more specific terms regarding the HPG axis, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are suppressed by increased serum estradiol (E2) levels, thus inhibiting GnRH production and by extension testosterone production in the testes.
The four main types used for HRT are estradiol valerate (EV), estradiol cypionate (EC), estradiol enanthate (EEn), and estradiol undecylate (EUn). Each of these is an “ester” of estradiol and will be converted to estradiol in your body.
+The four main types used for HRT are estradiol valerate (EV), estradiol cypionate (EC), estradiol enanthate (EEn), and estradiol undecylate (EUn). Each of these is an “ester” of estradiol (E2) and will be converted to estradiol in your body.
Please note that in some regions pills are confusingly sold with the name estradiol valerate, but this section only refers to the injectable form.
@@ -2151,7 +2151,7 @@No. There is not an arbitrary time where estrogen suddenly stops working. Various numbers are given and usually it’s either 1) entirely made up or 2) pointing to a study that only went for X years. Doctors in particular love to tell trans women not to expect more than B cup breasts (which isn’t even how breast sizing works, but I digress) or for any growth after 2 years, but this is simply not true. There are cases of people who restarted estrogen after stopping for many years and still experiencing new growth.
+No. There is not an arbitrary time where estrogen suddenly stops working. Various numbers are given and usually it’s either 1) entirely made up or 2) pointing to a study that only went for X years. Doctors in particular love to tell trans women not to expect more than B cup breasts (which isn’t even how breast sizing works, but I digress) or for any growth after 2 years, but this is simply not true. There are cases of people who restarted estrogen after stopping for many years and still experienced new growth.
Full Compilation Datetime: Fri Oct 24 00:40:33 2025
+Full Compilation Datetime: Fri Oct 24 13:01:14 2025
(There aren’t LaTeXML bindings for datetime2, hanging, or hyphenat, so the formatting is slightly ugly. If you’d really like to help me out, please write those bindings!!!)
@@ -2806,7 +2806,7 @@